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Isolated in the early 1970s, it has been extensively studied for its role in gene expression modulation, influencing over 4,000 genes linked to tissue remodeling and inflammation control

This result demonstrated specific interaction of 25HC with integrin molecules

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Beharier found that spontaneous preterm birth associated with placental dysfunction showed placental ferroptosis, accumulation of lipid peroxides in the placenta, and increased sensitivity of iPLA2-deficient trophoblast cells to ferroptosis [43]